Laser drilling is the best way to get close to the shape and morphology of the leaky holes and cracks occurring in nature. The leaky holes can be measured and verified by microscopy and velocity comparison.

The pipette's aperture can be as low as 0.1μm, but the tip is very fragile, so it is easy to be damaged in the process of sample preparation. It is necessary to be careful of the tip damage when preparing, and ensure that the pipette's surrounding seal is intact after implantation.

Capillaries are made of quartz material with a molten polymer coating. They are strong and flexible, and can be inserted into a variety of packaging materials, from plastic plugs to plastic glass, to simulate pores as small as 1μm or less.

Natural defect is a new type of positive sample that is the nearest to the actual glass crack prepared by artificial way. It is suitable for the packaging materials of conventional glass materials such as penicillin bottles and ampoule bottles. The aperture of natural defect can be less than 1 micron.